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The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sponsored this collaborative multi-center diabetes prevention and treatment program of research entitled the Studies to Treat or Prevent Type 2 Diabetes (STOPP-T2D). The treatment arm of the program is entitled Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY). This fifteen-center clinical trial compares three treatment arms on time to treatment failure based on glycemic control: metformin, metformin plus rosiglitazone, or meformin plus an intensive lifestyle intervention. Over 700 youth (ages 10 to 17 years) with type 2 diabetes and their families have been enrolled in the TODAY study nationwide.